This is why I'm glad that QMK exists. Because you're using a programmable board (where the keymaps/layers/etc) are stored on the keyboard itself you can move everything about and never worry about where your configuration is. And it runs all all sizes of boards from smaller stuff like [1] Gergo and GergoPlex to giant boards like the [2] Hyper7. Hell you can even get a addon board for a HHKB (Hasu Controller) and mod it in.
Although it's a bit of a rabbit hole. You start by moving around your control keys, maybe add a thumb backspace, a few months later you end up with a programming optimized symbols layer [3] and then maybe even adding in chorded stuff [4]. It's a bit of a trip and ruins 'traditional' keyboards.
The UK layout has an advantage, it's to the left of the Z and is easy to type.
The UK layout has a whole extra key which also makes # easier to type because it does not require a shift.