I believe you could. I can share the story from a bit different field. I was using a split keyboard with staggered layout and just built an Ergodox because wanted to try vertically staggered layout. Another differences are thumb clusters of keys on Ergodox and different firmware. So the layouts of both keyboards are very different and different customisations can be made.
The main thing which I was afraid of was the same as you've said - that I won't be able to change my muscle memory. Another thing - I won't be able to switch back the old keyboard (I expected to use it at the office) or even won't be able to use laptop keyboard anymore.
Surprisingly even after getting comfortable with Ergodox with totally different layout (different firmware is being used between keebs) I'm still able to jump between those easily. Maybe the first 5 mins are a bit harder but that is it. This surprises me what human brain is capable to do. Of course I still need to switch between keyboards regularly to not forget the layouts.
Not the same thing but we often are afraid of unknown.
The main thing which I was afraid of was the same as you've said - that I won't be able to change my muscle memory. Another thing - I won't be able to switch back the old keyboard (I expected to use it at the office) or even won't be able to use laptop keyboard anymore.
Surprisingly even after getting comfortable with Ergodox with totally different layout (different firmware is being used between keebs) I'm still able to jump between those easily. Maybe the first 5 mins are a bit harder but that is it. This surprises me what human brain is capable to do. Of course I still need to switch between keyboards regularly to not forget the layouts.
Not the same thing but we often are afraid of unknown.