"Dark mode" and "blue light" and so on remember me also of vertical mice to avoid strain in the "mouse hand". It is not the orientation of the mouse which hurts, it is holding that thing for hours. Solutions? Vary. Mostly using the keyboard for all appropriate tasks (contrary to typewriters you don't need much force to push a key) and place it in a comfortable distance for you, using a TrackPoint, a digitizer pen and tablet, using a bigger or smaller mouse appropriate for your hand and of course do something other with you're hand.