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> Coming into bio as a programmer, this is the absolute sin qua non rule you need to internalize: there are no boundaries between systems, because everything is jiggling atoms.

(Similar background as you.) Another sine qua non rule is that evolution created biology, it wasn't engineered like software and it doesn't decompose like software. Evolution creates hairballs that has don't respect traditional engineering boundaries and abstraction hierarchies.

From that, along with probabilistic molecular jiggling, we get biological systems that are quite difficult to understand, predict, and control.



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