The other thing these number chasers don’t tell you is that extremely low LDL numbers are also associated with anger management issues. The stuff is used in your body to build things. You need some, and probably at least half of the number this doc is trying to say is scary. In fact in a different test he is advised to talk to his doctor about whether a 29 is safe.
Has the guidance changed that you want LDL less than 2.5x (or was it 2x?) your HDLs?
Every organ in your body that utilizes LDL can synthesize it de novo. Some of the heaviest users, like your brain, literally can't get it from your serum LDL levels - they do not pass the blood brain barrier. It is all synthesized locally.
PKCS9 inhibitors and mendelian randomization studies show that people function just fine with <10 LDL-C. (Other comments I have made in here have links to all the relevant studies)
Googling for statin and aggression links I find a fairly small set of studies with fairly disparate outcomes.
I believe there was a time they thought statins were causing mood disturbances, but I was talking about unmedicated individuals with naturally low serum levels.
Has the guidance changed that you want LDL less than 2.5x (or was it 2x?) your HDLs?